Bisphosphonates Target B Cells to Enhance Humoral Immune Responses
نویسندگان
چکیده
منابع مشابه
Bisphosphonates target B cells to enhance humoral immune responses.
Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4(+) and γ...
متن کاملB cells enhance early innate immune responses during bacterial sepsis
Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect early innate inflammatory responses to viral infection, but both activation and suppression have been demonstrated. We identify a novel role for B cells in the early innate immune response during bacterial sepsis. We demonstrate that Rag1(-/-) mice display deficient early inflammatory responses and red...
متن کاملB cell-specific deficiencies in mTOR limit humoral immune responses.
Generation of high-affinity Abs in response to Ags/infectious agents is essential for developing long-lasting immune responses. B cell maturation and Ab responses to Ag stimulation require Ig somatic hypermutation (SHM) and class-switch recombination (CSR) for high-affinity responses. Upon immunization with either the model Ag 4-hydroxy-3-nitrophenylacetyl hapten (NP) conjugated to chicken γ gl...
متن کاملCarnauba Wax Nanoparticles Enhance Strong Systemic and Mucosal Cellular and Humoral Immune Responses to HIV-gp140 Antigen Running title: Nanoparticles enhance immune responses to HIV-gp140 antigen
متن کامل
Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.
B cells are pivotal regulators of acquired immune responses, and recent work in both experimental murine models and humans has demonstrated that subtle changes in the regulation of B cell function can substantially alter immunological responses. The balance of negative and positive signals in maintaining an appropriate B cell activation threshold is critical in B lymphocyte immune tolerance and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.09.004